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KMID : 1123920140280050499
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Korean Journal of Oriental Physiology and Pathology
2014 Volume.28 No. 5 p.499 ~ p.505
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Study of Immunosuppressive Activity and Insulin Secretion by Treated Sanguisorba Officinalis
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Hwang Seok-Youn
Kim Myung-Hyun
Kang Jung-Soo
Kim Byoung-Soo
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Abstract
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Immunosuppressors cyclosporine A(CsA) and tacrolimus(FK506), the primary cellular target of which is calcineurin/nuclear factor of activated T cells(NFAT) signalling pathways, decrease beta-cell insulin content and mRNA expression. The posttransplantation diabetes mellitus(PTDM) is a frequent complication in immunosuppressive therapy. The present study was to examine the effect of a crude water extracts of medicinal herbs such as Sanguisorba officinalis(SOE) on the immunosuppressive activity with lymphocyte and insulin secretion in insulinoma cell lines with RIN-5mF. It was found that SOE treatment had effect of immunosuppressor on lymphocytes and also significantly increased insulin secretion in RIN-5mF compared to other agents. we might suggest a mechanism on insulin secretion by HNF4a. Taken together, the present study suggested that SOE might serve as immunosuppressive drug in PTDM.
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KEYWORD
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Sanguisorba officinalis, immunosuppressor, insulin secretion, HNF-4α
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